[Efficacy of latanoprost versus travoprost assessed by daily intraocular pressure curve]. / Eficácia do latanoprosta x travoprosta avaliada pela curva diária de pressão intraocular.

PURPOSE: To assess the efficacy of latanoprost (L) and travoprost (T) as monotherapy as well as both drugs associated with 0.5% timolol maleate twice a day regarding the daily curve of intraocular pressure (DCPo) with the measurement of intraocular pressure (IOP) at 6 am in bed. METHODS: Retrospective study analyzing the daily curve of intraocular pressure of patients treated with L or T with or without 0.5% Tim. Patients who did not correctly follow the treatment were excluded. We also excluded the patients who used the prostaglandin analog associated with any other antiglaucomatous drug different from 0.5% Tim and those who were treated with more than two antiglaucomatous drugs. Statistical analysis was made through the SPSS 11.0 program calculating mean intraocular pressure (Pm), variability (V), p value and standard deviation. Ethnic aspects or type of glaucoma were no criteria of inclusion or exclusion in this study. RESULTS: Seventy-five patients (142 eyes) were included. The average age was 61.7 years. Thirty-three (44.0%) patients were male and 42 (56.0%) were female. Thirteen patients (26 eyes 18.3%) used L, 18 patients (33 eyes - 23.2%) were treated with T, 18 patients (32 eyes - 22.5%) used latanoprost and 0.5% timolol (L 0.5%Tim) and 26 patients (51 eyes - 35.9%) used travoprost and 0.5% timolol (T 0.5%Tim). Chronic simple glaucoma was the most common type (92.0%), followed by congenital glaucoma (6.7%) and glaucoma secondary to cataract surgery (1.3%). Pm was 15.2 (+/- 4.2) mmHg among those treated with L and 14.8 (+/- 3.2) mmHg among the T users. Those patients showed a V of 2.0 (+/- 1.2) and 3.2 (+/- 1.9). In the group of L 0.5%Tim and T 0.5%Tim the Pm and V were 14.9 (+/- 2.2) mmHg, 15.0 (+/- 3.2) mmHg, 2.4 (+/- 1.2) and 2.8 (+/- 1.6) respectively. No statistical significant difference was found in the Pm neither with the drugs used as monotherapy nor with them associated with 0.5% timolol maleate as well as in the V with both drugs associated with 0.5% timolol maleate. However, V showed a significant statistically difference when we considered the drugs in monotherapy, the IOP fluctuation being lower with L (t= -2.9; p=0.005). CONCLUSION: In the daily curve of intraocular pressure performed with the measurement of intraocular pressure at 6 am in bed, L and T associated with 0.5% timolol maleate had a similar efficacy; however, in monotherapy, Pm was similar in both drugs but the V obtained with L was lower the difference being statistically significant.

Eficácia do latanoprosta x travoprosta avaliada pela curva diária de pressão intraocular / Efficacy of latanoprost versus travoprost assessed by daily intraocular pressure curve

OBJETIVO: Avaliar, através da curva diária de pressão intraocular (CDPo), a eficácia do latanoprosta (L) e do travoprosta (T) como monoterapia e do L e T associados ao maleato de timolol 0,5 por cento (LTim 0,5 por cento e TTim 0,5 por cento) em pacientes glaucomatosos. MÉTODOS: Análise retrospectiva da curva diária de pressão intraocular de pacientes glaucomatosos em uso de L ou T ou das associações LTim 0,5 por cento e TTim 0,5 por cento. Foram excluídos os pacientes que não usaram a(s) medicação(ões) de maneira correta na curva diária de pressão intraocular e aqueles que estavam em uso de L ou T associado a outro hipotensor qão o timolol 0,5 por cento ou em uso de mais de dois colírios antiglaucomatosos. Foram analisados, em cada grupo, a pressão média (Pm) e a variabilidade (V) e seus respectivos desvios padrões. Utilizou-se o programa SPSS 11.0 na análise estatística. Raça, idade, sexo e tipo de glaucoma não foram critérios para a inclusão ou a exão dos pacientes. RESULTADOS: Foram incluídos 75 pacientes (142 olhos) com idade média de 61,7 anos, sendo 33 (44,0 por cento) do sexo masculino e 42 (56,0 por cento) do feminino. Treze pacientes (26 olhos - 18,3 por cento) usavam L; 18 pacientes (33 olhos - 23,2 por cento) usavam T; 18 pacientes (32 olhos - 22,5 por cento) estavam em tratamento com LTim 0,5 por cento e 26 pacientes (51 olhos - 35,9 por cento) usavam a associação TTim 0,5 por cento. Sessenta e nove pacientes (92,0 por cento) eram portadores de glaucoma crônico simples; 5 (6,7 por cento) de glaucoma congênito e 1 (1,3 por cento) de glaucoma pós-pseudofacia. Nos grupos L e T, os valores da Pm foram 15,2 (± 4,2) mmHg e 14,8 (±3,2) mmHg e os da V foram 2,0 (± 1,2) e 3,2 (± 1,9), respectivamente. Nos grupos LTim 0,5 por cento e TTim 0,5 por cento, os valores da Pm foram 14,9 (± 2,2) mmHg e 15,0 (±3,2) mmHg e os da V foram 2,4 (± 1,2) e 2,8 (± 1,6), respectivamente. Não houve diferença estatisticamente significativa na Pm entre ...

PURPOSE: To assess the efficacy of latanoprost (L) and travoprost (T) as monotherapy as well as both drugs associated with 0.5 percent timolol maleate twice a day regarding the daily curve of intraocular pressure (DCPo) with the measurement of intraocular pressure (IOP) at 6 am in bed. METHODS: Retrospective study analyzing the daily curve of intraocular pressure of patients treated with L or T with or without 0.5 percent Tim. Patients who did not correctly follow the treatment were excluded. We also excluded the patients who used the prostaglandin analog associated with any other antiglaucomatous drug different from 0.5 percent Tim and those who were treated with more than two antiglaucomatous drugs. Statistical analysis was made through the SPSS 11.0 program calculating mean intraocular pressure (Pm), variability (V), p value and standard deviation. Ethnic aspects or type of glaucoma were no criteria of inclusion or exclusion in this study. RESULTS: Seventy-five patients (142 eyes) were included. The average age was 61.7 years. Thirty-three (44.0 percent) patients were male and 42 (56.0 percent) were female. Thirteen patients (26 eyes 18.3 percent) used L, 18 patients (33 eyes - 23.2 percent) were treated with T, 18 patients (32 eyes - 22.5 percent) used latanoprost and 0.5 percent timolol (L 0.5 percentTim) and 26 patients (51 eyes - 35.9 percent) used travoprost and 0.5 percent timolol (T 0.5 percentTim). Chronic simple glaucoma was the most common type (92.0 percent), followed by congenital glaucoma (6.7 percent) and glaucoma secondary to cataract surgery (1.3 percent). Pm was 15.2 (± 4.2) mmHg among those treated with L and 14.8 (± 3.2) mmHg among the T users. Those patients showed a V of 2.0 (± 1.2) and 3.2 (± 1.9). In the group of L 0.5 percentTim and T 0.5 percentTim the Pm and V were 14.9 (± 2.2) mmHg, 15.0 (± 3.2) mmHg, 2.4 (± 1.2) and 2.8 (± 1.6) respectively. No statistical significant difference was found in the Pm neither ...